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2.8 EGF receptor and the Ras protein
 
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The EGF receptor functions as a tyrosine kinase (TK) EGF was found to have mitogenic effects when applied to a variety of epithelial cell types. EGF was able to bind to the surfaces of the cells whose growth it stimulated; other cells to which EGF was unable to bind were unresponsive to its mitogenic effects. An EGF receptor protein can specifically recognize EGF bind to it, and inform the cell interior The EGF receptor The cytoplasmic domain revealed a clear sequence similarity with the already-known sequence of the Src protein Signal activated EGF leads to the Src-like kinase in its cytoplasmic domain becoming activated to phosphorylate tyrosines on certain cytoplasmic proteins thereby causes a cell to proliferate. There are many receptor tyrosine kinases Subsequent sequencing efforts revealed overall sequence similarities among a variety of tyrosine kinases, many of which can function as oncoproteins. Truncated versions of the EGF receptor are found in a number of human tumor cell types. A variety of growth factor receptors that are configured much like the EGF receptor have been found in human tumors to be overexpressed or synthesized in a structurally altered form Autocrine signaling loops Some human cancers produce as many as three distinct growth factors Eg tumor growth factor-a, TGF-a stem cell factor; or SCF; insulin-like growth factor; or IGF At the same time express the receptors for these three ligands, thereby establishing three autocrine signaling loops simultaneously. In normal tissues, the proliferation of individual cells almost always depends on signals received from other cells Growth Factor activated receptors tyrosine kinase signal to ras “Ras” carry covalently attached lipid tails, composed of farnesyl, palmitoyl, and is anchored to cytoplasmic membranes the Ras molecule seemed to behave like a light switch that automatically turns itself off after a certain predetermined time. Ras switching Ras was found to bind a GDP molecule when in its quiescent, inactive state to jettison its bound GDP after receiving some stimulatory signal from upstream in a signaling cascade to acquire a GTP molecule in place of the recently evicted GDP to shift into an activated, signal-emitting configuration while binding this GTP to cleave this GTP after a short period by using its own intrinsic GTPase function Signalling to “Ras” Mitogenic signals, transduced in some way by tyrosine kinase receptors, activated a guanine nucleotide exchange factor (GEF) for Ras. Ras receives signals from upstream in a signalling cascade subsequently passes these signals on to a downstream targets How does “Ras” signal? Ras can operate as an oncoprotein: Typically mutations strike either the 12th or the 61st codon of the reading frame of the ras gene Rather than sending out short, carefully rationed pulses of growth-stimulating signals, the oncoprotein emits these signals for a long, indefinite period of time. Thereby flooding the cell with these signals Why do point mutations Activate oncogenes Large-scale alterations of the ras proto-oncogenes, such as deletions, are clearly not productive for cancer, they result in the elimination of Ras protein function The vast majority of point mutations striking ras protooncogenes yield mutant Ras proteins that have lost rather than gained the ability to emit growth-stimulatory signals. Only when the signal-emitting powers of Ras are left intact and its GTPase negative-feedback mechanism is inactivated does the Ras protein gain increased power to drive cell proliferation and transform the cell. Point mutations in the GTPase domain keep ras active
Views: 2526 Mark Temple
Ran GTPase, GAP, GEF
 
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The dynamic process between the cytosol and the nucleus of how Ran-GDP cycles with Ran-GTP
Views: 874 kaleidoscopicKT
Figure 18.17 Determining the guanine nucleotide exchange properties of EF-Ts
 
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This video describes an experiment that shows that EF-Ts promotes the release of GDP from EF-Tu. This is figure 18.17 from Molecular Biology 5th edition by Robert Weaver. It was made for MCDB 427, a molecular biology course at the University of Michigan.
Views: 46 MCDB 427
Molecular Cloning of Rho Family Guanine Nucleotide Exchange Factors FGD1-5
 
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Student Achievement Day Presentation at Bemidji State University
Views: 124 bawani129
Medical vocabulary: What does ras Guanine Nucleotide Exchange Factors mean
 
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What does ras Guanine Nucleotide Exchange Factors mean in English?
Views: 11 botcaster inc. bot
G Protein linked 2nd Messengers, G protein coupled receptors, GPCRs
 
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Understand the G-protein receptors like never before!!! Thanks for watching! I love making these for you! I'm constantly trying to make (and find) better videos for you to study from **it’s not easy! **You can help by suggesting any good videos you've seen in the comments below! Good luck in school!! I'm sure that you've talked about the G protein-linked receptors in school, however, you might not have called them G protein-linked receptors. They go by other names like G protein-linked second messengers or G protein-coupled receptors, that's a pretty common one. Even conversationally, a lot of people just say the G proteins. I'm gonna break down those words a little bit later and tell you what each part of it means and why we use those names to refer to these proteins. But first off, what does the G stand for? Why is it G protein? Well, the G stands for guanine. These are guanine nucleotide-binding proteins, meaning that they bind guanine nucleotides. Like for example guanosine triphosphate or its slightly shorter little brother, guanosine diphosphate. These receptors are extremely important physiologically. We use them all over our body and they do all kinds of different functions. These receptors are only found in eukaryotes and are the target of about 40% of all the drugs we use in medicine today. I just told you that they're very diverse in function however, there's two main signal transduction pathways that you got to know, you have to know them for your boards and that is the cyclic AMP-dependent pathway and the phosphatidylinositol signal pathway, okay? I'll talk about those more in a little bit. First, let's jump into the structure and function of these things, it's pretty cool. I told you that I was going to breakdown the names so that you can understand the concepts a little bit better. First off, let's get started with what does the word "G proteins" mean? Well, the G proteins are a component of this receptor system. The G proteins are heterotrimeric GTP-binding proteins made of three subunits, hence, heterotrimeric. First there's the alpha subunit, then the beta subunit and then the gamma subunit. And you should also notice from my illustration here that the beta and gamma subunits are more tightly linked together than the two are to the alpha subunit. Actually the beta and the gamma stay connected where the alpha subunit separates itself in normal function. These G proteins live on the intracellular side of the cell membrane and are attached to or connected to the cell membrane itself by lipid anchors. The next thing for us to talk about is to define what are the G protein-coupled receptors? Well, these are receptors that live in the membrane and in fact, they pass through the membrane seven times which is an important number, you might be tested on it. All right, so these G protein-coupled receptors interact with the G proteins and cause oftentimes a confirmational change so that the alpha subunit of the G protein can accept different nucleotides. What about the term G protein-linked second messengers? Well, that's another component of this system which are cellular target-proteins or enzymes that perform some kind of function when they interact with the G proteins that we've already talked about. Now they are very diverse but as I said in the beginning, there's two main pathways or two main targets that cause a pathway that you have to understand. And those two are the cyclic AMP-dependent pathway and the phosphatidylinositol signal pathway, which I abbreviate here as IP3/DAG pathway. Right now you're probably thinking, Dr. Joel, I have no idea what you're talking about. Don't worry, I will show you the whole thing working and we'll talk about the parts as we go, and I'm pretty sure that it will make sense after we go through it. First, we have to set the stage a little bit. The G proteins or more specifically, the alpha subunit of the G proteins is bound in its resting state to guanosine diphosphate or GDP. In this state, the receptor is just sitting and waiting. On the extracellular side of the cell membrane, a ligand comes and it binds with the G protein-coupled receptor causing a confirmational change. The confirmational change allows the alpha subunit to bind with guanosine triphosphate and release the guanosine diphosphate. Now, the G proteins are active and as active G proteins, they do a couple of things. First off, the alpha subunit separates itself from the beta gamma complex. This kind of frees it up a little bit so it's free to move around. It's still attached to the membrane by a lipid anchor but the lipid anchor can kind of swim through the membranes. It's able to move to the target. It moves the target and it causes the target protein or enzyme to change in some way. Either the G protein interaction causes the target to speed up what it's doing or slow down what it's doing or stop what it's doing. It does something to the target protein.
Views: 49480 Med Immersion
Alfred Wittinghofer (MPI) Part 1: GTP-binding Proteins as Molecular Switches
 
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https://www.ibiology.org/biochemistry/g-protein/ When a growth factor binds to the plasma membrane of a quiescent cell, an intracellular signaling pathway is activated telling the cell to begin growing. A key molecule in this signaling pathway is the GTP-binding protein, or G-protein, Ras. Ras can act as an on-off switch telling the cell to grow or not. In its inactive form, Ras is bound to GDP while in its active form it is bound to GTP. This exchange of nucleotides is catalysed by guanine nucleotide-exchange-factors (GEFs). The return to the inactive state occurs through the GTPase reaction, which is accelerated by GTPase-activating proteins (GAPs). In Part 1 of his talk, Dr. Wittinghofer explains how solving the three-dimensional structure of Ras, and other G-proteins, allowed him to understand the conserved mechanism by which G-proteins can act as switches. The structure also identified domains unique to each G-protein that provide the specificity for downstream signals.
Views: 31347 iBiology
02 Oncogenes
 
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A presentation on Cancer Genetics discussing Oncogenes and the Ras signalling protein as an example. Cellular Oncogenes The cell genome is rich source of the genes that drive human cancer The cellular genome has tens of thousands of genes. A large catalog of cellular cancer-causing genes has been assembled. These are called oncogenes and tumor suppressor genes Consider the H-ras gene The oncogene that had been cloned from human bladder carcinoma cells caused transformation of NIH 3T3 cells, while its normal proto-oncogene counterpart (i.e., the normal Hras gene) lacked this ability. A 350-bp segments from the proto-oncogene and oncogene were subjected to DNA sequence analysis. The critical difference was extraordinarily subtle—a single base substitution in which a G (guanosine) residue in the proto-oncogene was replaced by a T (thymidine) in the oncogene. This single base-pair replacement - a point mutation - appeared to be all that was required to convert the normal gene into a potent oncogene The H-ras gene This was the first time that a mutation was discovered in a gene that contributed to the growth of a human cancer. This genetic change arose as a somatic mutation. The importance of Ras proteins in tumors In the 1980s, it was demonstrated that close to 30% of all solid tumors in humans show a mutation in the Ras gene. Certain positions in the Ras protein are particularly sensitive to oncogenic mutations. Replacement of Gly12 in the Ras protein with any of the other natural amino acids (except Pro) leads to an increase in the tumor-transforming potential of Ras protein. RAS a switch protein Structure and Biochemical Properties of Ras Protein The Ras protein is a GTPase the GTP-bound form represents the active, switched-on state the GDP-bound form is the inactive, switched-off state The transition between the active and inactive forms occurs in a unidirectional cycle The Ras activation cycle Ras On… GEF Guanine Exchange Factors Sos protein Is a GEF that provokes nucleotide exchange by G proteins (guanine nucleotide-binding), such as Ras. Ras Off… GAP GTPase Activating Protein GTPase-activating proteins (GAP), increase the rate of GTP hydrolysis of the Ras protein up to 105-fold. reducing the lifetime of the active GTP state. Due to this property, they function as negative regulators of the Ras protein. Cancer Genetics in brief series… by Mark Temple
Views: 3944 Mark Temple
Medical vocabulary: What does ral Guanine Nucleotide Exchange Factor mean
 
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What does ral Guanine Nucleotide Exchange Factor mean in English?
Views: 136 botcaster inc. bot
Ras activator, Son of sevenless
 
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Ras is a proto-oncogene and is a member of small-molecular weight GTP binding protein family. This movie shows the mechanism of Ras activation by Sos (son of sevenless), a guanine-nucleotide exchange factor for Ras. The Cdc25-HD domain of Sos inserts into switch regions of Ras and excludes the binding of a guanine nucleotide and a magnesium ion, so that a GTP can be recruited subsequently. These structures also show a sophisticated mechanism for positive feedback regulation. A second molecule of Ras in its activated GTP-bound form interacts with the Cdc25-HD domain and its upstream REM domain to arrange the Sos domains for GTP exchange of the first Ras. In addition, the second Ras binding also inhibits the interaction with the auto-inhibitory DH-PH domains.
Views: 3589 StructureForBiology
4.3 How is ras involved in signaling
 
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How is ras involved in the signaling Ras (oncogene) was known to be important in cancer Ras was known to be a molecular switch But was ras involved in the signaling from receptor to nucleus If so how? Ras as a molecular switch involves a conformational change Eye development in the fruit fly Drosophila melanogaster The gene sevenless - in its absence, the seventh cell in each ommatidium failed to form After cloning and sequencing the sevenless gene was found to encode a tyrosine kinase receptor (a bit like the EGF receptor) Eye development in the fruit fly other mutations mimicked sevenless Could this be a linear signal-transduction cascade e.g. son of sevenless (sos) Sos protein related to yeast proteins that provoking nucleotide exchange by G proteins (guanine nucleotide-binding), such as Ras. Other proteins make the pathway Shc (pronounced "shick”) Grb2 (pronounced "grab two”) We know have... GF-- TKR-- Grb2-- Sos-- Ras But... what is the role of Tyrosine Phosphorylation? Was the phosphorylation of these receptors on tyrosine residues critical to their ability to signal or was it a distraction? If this phosphorylation was important how could it activate the complex signaling circuitry downstream?
Views: 914 Mark Temple
Medical vocabulary: What does Rho Guanine Nucleotide Exchange Factors mean
 
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What does Rho Guanine Nucleotide Exchange Factors mean in English?
Views: 29 botcaster inc. bot
Medical vocabulary: What does Guanine Nucleotide Exchange Factors mean
 
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What does Guanine Nucleotide Exchange Factors mean in English?
Views: 119 botcaster inc. bot
Medical vocabulary: What does ras Guanine Nucleotide Exchange Factors mean
 
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What does ras Guanine Nucleotide Exchange Factors mean in English?
Views: 11 botcaster inc. bot
Gene Music using Protein Sequence of VAV3 "VAV 3 GUANINE NUCLEOTIDE EXCHANGE FACTOR"
 
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Gene Music using Protein Sequence of VAV3 "VAV 3 GUANINE NUCLEOTIDE EXCHANGE FACTOR" Welcome to Gene Music Studio. Hope you can have a taste (visually & musically) of gene information (particularly protein sequences) in this channel. Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music using Protein Sequence of TRIO "TRIO RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR"
 
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Gene Music using Protein Sequence of TRIO "TRIO RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1 Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences).
Views: 46 Gene Music Studio
Crucial step in cell division discovered
 
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Crucial step in cell division discovered Crucial step in cell division discovered Cancer Research UK scientists have discovered how cells 'pinch in' at the middle in order to split into two new cells. Their research is published in Developmental Cell today. http://medicalxpress.com/news/2011-12-crucial-cell-division.html Reference Targeting of the Rho-Exchange Factor Ect2 to the Equatorial Membrane Controls the Initiation of Cytokinesis. Developmental Cell, Volume 21, Issue 6, 1104-1115, 13 December 2011 DOI: 10.1016/j.devcel.2011.11.003 http://www.cell.com/developmental-cell/retrieve/pii/S1534580711005132 Highlights •Live-cell imaging reveals equatorial membrane localization of Ect2 at cytokinesis •Membrane association of Ect2 requires a pleckstrin domain and polybasic cluster •GEF activity and membrane targeting of Ect2 control cleavage furrow formation •Central spindlin and CDK1 activity control Ect2 membrane targeting in space and time Summary In animal cells, formation of the cytokinetic furrow requires activation of the GTPase RhoA by the guanine nucleotide exchange factor Ect2. How Ect2, which is associated with the spindle midzone, controls RhoA activity at the equatorial cortex during anaphase is not understood. Here, we show that Ect2 concentrates at the equatorial membrane during cytokinesis in live cells. Ect2 membrane association requires a pleckstrin homology domain and a polybasic cluster that bind to phosphoinositide lipids. Both guanine nucleotide exchange function and membrane targeting of Ect2 are essential for RhoA activation and cleavage furrow formation in human cells. Membrane localization of Ect2 is spatially confined to the equator by centralspindlin, Ect2's spindle midzone anchor complex, and is temporally coordinated with chromosome segregation through the activation state of CDK1. We propose that targeting of Ect2 to the equatorial membrane represents a key step in the delivery of the cytokinetic signal to the cortex.
Views: 3374 Stefano Di Criscio
Gene Music using Protein Sequence of ARHGEF12 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF) 12"
 
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Gene Music using Protein Sequence of ARHGEF12 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF) 12" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1 Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences).
Views: 19 Gene Music Studio
Gene Music using Protein Sequence of RIC8A "RIC8 GUANINE NUCLEOTIDE EXCHANGE FACTOR A"
 
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Gene Music using Protein Sequence of RIC8A "RIC8 GUANINE NUCLEOTIDE EXCHANGE FACTOR A" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Conformational Change from active (GTP bound) to inactive (GDP bound) state of H-Ras protein.
 
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Watch in 480p for best quality. Ras are a group of small GTPases which are activated by binding of GTP( Guanosine tri phosphate) a process which is facilated by GEF (Guanine nucleotide exchange factor) protein. The Ras which then activates its cellular target for conveying the signal downstream then hydrolyses the bound GTP ( process stimulated by another protein GAP (GTPase Activating Protein) to GDP which the dissociates and the protein returns to its inactive conformation.
Views: 5268 Perunamuusi
Gene Music using Protein Sequence of RABGEF1 "RAB GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF) 1"
 
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Gene Music using Protein Sequence of RABGEF1 "RAB GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF) 1" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music Using Protein Sequence of ARHGEF38 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 38"
 
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Gene Music Using Protein Sequence of ARHGEF38 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 38"
Views: 20 Gene Music Studio
Medical vocabulary: What does Guanine Nucleotide Dissociation Inhibitors mean
 
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What does Guanine Nucleotide Dissociation Inhibitors mean in English?
Views: 21 botcaster inc. bot
Gene Music using Protein Sequence of SOS1 "SOS RAS/RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"
 
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Gene Music using Protein Sequence of SOS1 "SOS RAS/RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR 1" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1 Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences).
[Wikipedia] RhoGEF domain
 
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RhoGEF domain is a structural domain of guanine nucleotide exchange factors for Rho/Rac/Cdc42-like GTPases. It is also called "Dbl-homologous" (DH) domain. https://en.wikipedia.org/wiki/RhoGEF_domain Please support this channel and help me upload more videos. Become one of my Patreons at https://www.patreon.com/user?u=3823907
Views: 15 WikiTubia
Gene Music using Protein Sequence of ARHGEF2 "RHO/RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR 2"
 
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Gene Music using Protein Sequence of ARHGEF2 "RHO/RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR 2" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1 Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences).
Gene Music using Protein Sequence of VAV1 "VAV GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"
 
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Gene Music using Protein Sequence of VAV1 "VAV GUANINE NUCLEOTIDE EXCHANGE FACTOR 1" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1 Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences).
Gene Music using Protein Sequence of ARHGEF11 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 11"
 
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Gene Music using Protein Sequence of ARHGEF11 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 11" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1 Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences).
Gene Music using Protein Sequence of RAPGEF5 "RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 5"
 
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Gene Music using Protein Sequence of RAPGEF5 "RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 5" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music using Protein Sequence of RAPGEFL1 "RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR LIKE 1"
 
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Gene Music using Protein Sequence of RAPGEFL1 "RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR LIKE 1"
Views: 22 Gene Music Studio
Gene Music using Protein Sequence of RAPGEF4 "RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4"
 
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Gene Music using Protein Sequence of RAPGEF4 "RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1 Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences).
Gene Music using Protein Sequence of ARHGEF1 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"
 
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Gene Music using Protein Sequence of ARHGEF1 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music using Protein Sequence of ARHGEF6 "RAC/CDC42 GUANINE NUCLEOTIDE EXCHANGE FACTOR 6"
 
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Gene Music using Protein Sequence of ARHGEF6 "RAC/CDC42 GUANINE NUCLEOTIDE EXCHANGE FACTOR 6" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music using Protein Sequence of RIC8B "RIC8 GUANINE NUCLEOTIDE EXCHANGE FACTOR B"
 
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Gene Music using Protein Sequence of RIC8B "RIC8 GUANINE NUCLEOTIDE EXCHANGE FACTOR B" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music using Protein Sequence of RAPGEF6 "RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6"
 
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Gene Music using Protein Sequence of RAPGEF6 "RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1 Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences).
Views: 11 Gene Music Studio
Gene Music using Protein Sequence of ARHGEF5 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 5"
 
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Gene Music using Protein Sequence of ARHGEF5 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 5" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1 Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences).
Gene Music using Protein Sequence of ARHGEF33 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 33"
 
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Gene Music using Protein Sequence of ARHGEF33 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 33" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music using Protein Sequence of RAPGEF1 "RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"
 
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Gene Music using Protein Sequence of RAPGEF1 "RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1 Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences).
Gene Music using Protein Sequence of ARHGEF7 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7"
 
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Gene Music using Protein Sequence of ARHGEF7 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Medical vocabulary: What does rho-Specific Guanine Nucleotide Dissociation Inhibitors mean
 
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What does rho-Specific Guanine Nucleotide Dissociation Inhibitors mean in English?
The Universe of GTP-binding proteins: un tema con variationi
 
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Air date: Wednesday, March 25, 2009, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local Category: Wednesday Afternoon Lectures Description: GTP binding (G) proteins of the Ras superfamily cycle between a GDP-bound inactive and a GTP-bound active state. The switch-ON reaction involves the exchange of tightly bound GDP against GTP, while the switch-OFF mechanism involves the enzymatic cleavage of GTP to GDP. The switch function is tightly regulated since those reactions are intrinsically very slow and are stimulated through factors acting in trans. The first reaction is catalysed by guanine nucleotide exchange factors, GEFs, while the second is activated by GTPase-activating proteins called GAPs. The inability of certain of these proteins to be down-regulated or their unregulated activation leads to various forms of diseases including cancer. A lot is known about the structural requirements for the switch function of Ras proteins, the GEF and the GAP reaction, their membrane recruitment and the interaction with effectors. The basic features and mechanistic principles using Ras and G proteins, the structural basis of the molecular switch, how it is activated and how it interacts with downstream effectors, will be presented. Particular attention will be given to the GTPase reaction and its importance for disease formation such as cancer, Retinitis pigmentosa or Parkinson. The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. Author: Alfred Wittenhofer Runtime: 00:58:32 Permanent link: http://videocast.nih.gov/launch.asp?14996
Views: 1213 nihvcast
Medical vocabulary: What does rho Guanine Nucleotide Dissociation Inhibitor beta mean
 
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What does rho Guanine Nucleotide Dissociation Inhibitor beta mean in English?
Gene Music using Protein Sequence of SERGEF "SECRETION REGULATING GUANINE NUCLEOTIDE EXCHANGE FACTO"
 
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Gene Music using Protein Sequence of SERGEF "SECRETION REGULATING GUANINE NUCLEOTIDE EXCHANGE FACTO"
Gene Music using Protein Sequence of ARHGEF26 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 26"
 
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Gene Music using Protein Sequence of ARHGEF26 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 26" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music using Protein Sequence of RAPGEF2 "RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 2"
 
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Gene Music using Protein Sequence of RAPGEF2 "RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 2" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1 Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences).
Gene Music using Protein Sequence of ARHGEF16 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 16"
 
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Gene Music using Protein Sequence of ARHGEF16 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 16" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music using Protein Sequence of DEF6 "DEF6 GUANINE NUCLEOTIDE EXCHANGE FACTOR"
 
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Gene Music using Protein Sequence of RAPGEF3 "RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 3"
 
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Gene Music using Protein Sequence of RAPGEF3 "RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 3" In Gene Music Studio, everyone can get a taste (visually & musically) of gene information (particularly protein sequences). Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1

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