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Search results “Guanine exchange factor”
Ran GTPase, GAP, GEF
 
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The dynamic process between the cytosol and the nucleus of how Ran-GDP cycles with Ran-GTP
Views: 757 kaleidoscopicKT
2.8 EGF receptor and the Ras protein
 
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The EGF receptor functions as a tyrosine kinase (TK) EGF was found to have mitogenic effects when applied to a variety of epithelial cell types. EGF was able to bind to the surfaces of the cells whose growth it stimulated; other cells to which EGF was unable to bind were unresponsive to its mitogenic effects. An EGF receptor protein can specifically recognize EGF bind to it, and inform the cell interior The EGF receptor The cytoplasmic domain revealed a clear sequence similarity with the already-known sequence of the Src protein Signal activated EGF leads to the Src-like kinase in its cytoplasmic domain becoming activated to phosphorylate tyrosines on certain cytoplasmic proteins thereby causes a cell to proliferate. There are many receptor tyrosine kinases Subsequent sequencing efforts revealed overall sequence similarities among a variety of tyrosine kinases, many of which can function as oncoproteins. Truncated versions of the EGF receptor are found in a number of human tumor cell types. A variety of growth factor receptors that are configured much like the EGF receptor have been found in human tumors to be overexpressed or synthesized in a structurally altered form Autocrine signaling loops Some human cancers produce as many as three distinct growth factors Eg tumor growth factor-a, TGF-a stem cell factor; or SCF; insulin-like growth factor; or IGF At the same time express the receptors for these three ligands, thereby establishing three autocrine signaling loops simultaneously. In normal tissues, the proliferation of individual cells almost always depends on signals received from other cells Growth Factor activated receptors tyrosine kinase signal to ras “Ras” carry covalently attached lipid tails, composed of farnesyl, palmitoyl, and is anchored to cytoplasmic membranes the Ras molecule seemed to behave like a light switch that automatically turns itself off after a certain predetermined time. Ras switching Ras was found to bind a GDP molecule when in its quiescent, inactive state to jettison its bound GDP after receiving some stimulatory signal from upstream in a signaling cascade to acquire a GTP molecule in place of the recently evicted GDP to shift into an activated, signal-emitting configuration while binding this GTP to cleave this GTP after a short period by using its own intrinsic GTPase function Signalling to “Ras” Mitogenic signals, transduced in some way by tyrosine kinase receptors, activated a guanine nucleotide exchange factor (GEF) for Ras. Ras receives signals from upstream in a signalling cascade subsequently passes these signals on to a downstream targets How does “Ras” signal? Ras can operate as an oncoprotein: Typically mutations strike either the 12th or the 61st codon of the reading frame of the ras gene Rather than sending out short, carefully rationed pulses of growth-stimulating signals, the oncoprotein emits these signals for a long, indefinite period of time. Thereby flooding the cell with these signals Why do point mutations Activate oncogenes Large-scale alterations of the ras proto-oncogenes, such as deletions, are clearly not productive for cancer, they result in the elimination of Ras protein function The vast majority of point mutations striking ras protooncogenes yield mutant Ras proteins that have lost rather than gained the ability to emit growth-stimulatory signals. Only when the signal-emitting powers of Ras are left intact and its GTPase negative-feedback mechanism is inactivated does the Ras protein gain increased power to drive cell proliferation and transform the cell. Point mutations in the GTPase domain keep ras active
Views: 2285 Mark Temple
Nuclear Import and Export
 
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Some Notes to go with the video (recommended to read after the video) Protein sorting between the nucleus and the cytosol is termed gated transport, with the gate being the nuclear pore complex, or NPC. The nucleus has a double membrane surrounding it called the nuclear envelope. The nucleus allows passive entry and exit of small molecules (smaller than 5000 daltons) but controls the passage of macromolecules like proteins, many of which are in the range of ~25,000 daltons, as well as DNA and RNA polymerases, many of which are around 100 – 200 THOUSAND daltons. Ribosomes, which are huge, actually get assembled in the nucleus and must then be exported – being 30 nm across, they can’t get back in from the cytosol. The nuclear pore complex contains channel nucleoporins with large unstructured regions creating a messy tangle. This is why macromolecules can’t freely come and go but small molecules can. In order to enter the nucleus, a macromolecule needs a nuclear localization signal, or NLS, and in order to exit, it needs a nuclear export signal, or NES. With active transport, molecules up to 39 nm across can be carried through the nuclear pore complex. Protein cargo destined to be transported into the nucleus has a Nuclear Localization Signal (NLS) rich in positively-charged Lysine and Arginine amino acids, which allows it to bind to a Nuclear Import Receptor, also called an Importin. Different cargo proteins can have different nuclear localization signals and can therefore bind different importins. An adaptor is sometimes necessary to help the importin bind the cargo. The Importin binds to nucleoporins, at binding sites with many phenylalanine glycine repeats termed FG-repeats, in the Nuclear Pore Complex and is transported into the nucleus. The Nuclear Export Signal on macromolecules destined to leave the nucleus has a different amino acid sequence than the nuclear import sequence. The nuclear export receptor also binds to nucleoporins in the nuclear pore complex and is similar in structure to the nuclear import receptor. In fact, they are both encoded by a gene family called the karyopherins, or nuclear transport receptors. Now, let’s take a look at how nuclear import works A macromolecule has a nuclear localization signal and is hence destined to be transported into the nucleus. It binds to an importin and the bound importin binds to nucleoporins of the nuclear pore complex. The cargo-bearing importin is shuttled across. At the other end of the nuclear pore complex, there is a Ran GTP. Ran GTP binds the importin, which has a sort of stacked alpha helix motif forming a spring-like structure. The spring-like structure has a conformational change and the cargo protein is released into the nuclear lumen, which is its destination. After this exchange, the importin bound to Ran-GTP is transported back into the cytoplasm. Ran-GTP is hydrolyzed to Ran-GDP and inorganic phosphate and dissociates from the importin. The importin can now be reused to transfer the next cargo. For simplicity’s sake, I omitted a few details in the previous explanation. There are a few more players involved in nuclear import (and also export). Firstly, Ran is inefficient at GTP hydrolysis. And so Ran Binding Protein (RBP) – not shown here – and Ran GAP must work together to hydrolyze GTP and release the nuclear import receptor. An easy way to remember Ran-GAP is to think of it as… LITERALLY… creating a GAP where there used to be a phosphate group. Secondly, we have Nuclear Transport Factor 2, or NTF2 for short, which transports Ran-GDP into the nucleus. Inside the nucleus, we have Ran-GEF (Guanine Exchange Factor). Ran-GEF is bound to chromatin, and catalyzes Ran to exchange GDP for GTP. Upon completion, NTF2 returns to the cytoplasm. Here’s an brief overview of import. Feel free to pause the video and read. Nuclear Export is very similar to Import so I’m going to cover it quickly. A nuclear export receptor binds to nucleoporins and is transported into the nuclear lumen. There it binds with Ran-GTP, which then promotes binding with its nuclear export signal-bearing cargo. The receptor again binds to nucleoporins and the whole thing is transported to the cytosol. Ran-GAP helps with hydrolysis of Ran-GTP to Ran GDP and Ran Binding Protein helps detach Ran from the receptor. The cargo dissociates and the nuclear export receptor is free. Now, the receptor returns to the nucleus without any enzymes helping it.
Views: 55988 Neural Academy
Alfred Wittinghofer (MPI) Part 1: GTP-binding Proteins as Molecular Switches
 
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https://www.ibiology.org/biochemistry/g-protein/ When a growth factor binds to the plasma membrane of a quiescent cell, an intracellular signaling pathway is activated telling the cell to begin growing. A key molecule in this signaling pathway is the GTP-binding protein, or G-protein, Ras. Ras can act as an on-off switch telling the cell to grow or not. In its inactive form, Ras is bound to GDP while in its active form it is bound to GTP. This exchange of nucleotides is catalysed by guanine nucleotide-exchange-factors (GEFs). The return to the inactive state occurs through the GTPase reaction, which is accelerated by GTPase-activating proteins (GAPs). In Part 1 of his talk, Dr. Wittinghofer explains how solving the three-dimensional structure of Ras, and other G-proteins, allowed him to understand the conserved mechanism by which G-proteins can act as switches. The structure also identified domains unique to each G-protein that provide the specificity for downstream signals.
Views: 30612 iBiology
Medical vocabulary: What does Rho Guanine Nucleotide Exchange Factors mean
 
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What does Rho Guanine Nucleotide Exchange Factors mean in English?
Views: 29 botcaster inc. bot
NUCLEAR IMPORT AND EXPORT (IMPROVED AUDIO)
 
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Some Notes to go with the video (recommended to read after the video) Protein sorting between the nucleus and the cytosol is termed gated transport, with the gate being the nuclear pore complex, or NPC. The nucleus has a double membrane surrounding it called the nuclear envelope. The nucleus allows passive entry and exit of small molecules (smaller than 5000 daltons) but controls the passage of macromolecules like proteins, many of which are in the range of ~25,000 daltons, as well as DNA and RNA polymerases, many of which are around 100 – 200 THOUSAND daltons. Ribosomes, which are huge, actually get assembled in the nucleus and must then be exported – being 30 nm across, they can’t get back in from the cytosol. The nuclear pore complex contains channel nucleoporins with large unstructured regions creating a messy tangle. This is why macromolecules can’t freely come and go but small molecules can. In order to enter the nucleus, a macromolecule needs a nuclear localization signal, or NLS, and in order to exit, it needs a nuclear export signal, or NES. With active transport, molecules up to 39 nm across can be carried through the nuclear pore complex. Protein cargo destined to be transported into the nucleus has a Nuclear Localization Signal (NLS) rich in positively-charged Lysine and Arginine amino acids, which allows it to bind to a Nuclear Import Receptor, also called an Importin. Different cargo proteins can have different nuclear localization signals and can therefore bind different importins. An adaptor is sometimes necessary to help the importin bind the cargo. The Importin binds to nucleoporins, at binding sites with many phenylalanine glycine repeats termed FG-repeats, in the Nuclear Pore Complex and is transported into the nucleus. The Nuclear Export Signal on macromolecules destined to leave the nucleus has a different amino acid sequence than the nuclear import sequence. The nuclear export receptor also binds to nucleoporins in the nuclear pore complex and is similar in structure to the nuclear import receptor. In fact, they are both encoded by a gene family called the karyopherins, or nuclear transport receptors. Now, let’s take a look at how nuclear import works A macromolecule has a nuclear localization signal and is hence destined to be transported into the nucleus. It binds to an importin and the bound importin binds to nucleoporins of the nuclear pore complex. The cargo-bearing importin is shuttled across. At the other end of the nuclear pore complex, there is a Ran GTP. Ran GTP binds the importin, which has a sort of stacked alpha helix motif forming a spring-like structure. The spring-like structure has a conformational change and the cargo protein is released into the nuclear lumen, which is its destination. After this exchange, the importin bound to Ran-GTP is transported back into the cytoplasm. Ran-GTP is hydrolyzed to Ran-GDP and inorganic phosphate and dissociates from the importin. The importin can now be reused to transfer the next cargo. For simplicity’s sake, I omitted a few details in the previous explanation. There are a few more players involved in nuclear import (and also export). Firstly, Ran is inefficient at GTP hydrolysis. And so Ran Binding Protein (RBP) – not shown here – and Ran GAP must work together to hydrolyze GTP and release the nuclear import receptor. An easy way to remember Ran-GAP is to think of it as… LITERALLY… creating a GAP where there used to be a phosphate group. Secondly, we have Nuclear Transport Factor 2, or NTF2 for short, which transports Ran-GDP into the nucleus. Inside the nucleus, we have Ran-GEF (Guanine Exchange Factor). Ran-GEF is bound to chromatin, and catalyzes Ran to exchange GDP for GTP. Upon completion, NTF2 returns to the cytoplasm. Here’s an brief overview of import. Feel free to pause the video and read. Nuclear Export is very similar to Import so I’m going to cover it quickly. A nuclear export receptor binds to nucleoporins and is transported into the nuclear lumen. There it binds with Ran-GTP, which then promotes binding with its nuclear export signal-bearing cargo. The receptor again binds to nucleoporins and the whole thing is transported to the cytosol. Ran-GAP helps with hydrolysis of Ran-GTP to Ran GDP and Ran Binding Protein helps detach Ran from the receptor. The cargo dissociates and the nuclear export receptor is free. Now, the receptor returns to the nucleus without any enzymes helping it.
Views: 859 Neural Academy
02 Oncogenes
 
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A presentation on Cancer Genetics discussing Oncogenes and the Ras signalling protein as an example. Cellular Oncogenes The cell genome is rich source of the genes that drive human cancer The cellular genome has tens of thousands of genes. A large catalog of cellular cancer-causing genes has been assembled. These are called oncogenes and tumor suppressor genes Consider the H-ras gene The oncogene that had been cloned from human bladder carcinoma cells caused transformation of NIH 3T3 cells, while its normal proto-oncogene counterpart (i.e., the normal Hras gene) lacked this ability. A 350-bp segments from the proto-oncogene and oncogene were subjected to DNA sequence analysis. The critical difference was extraordinarily subtle—a single base substitution in which a G (guanosine) residue in the proto-oncogene was replaced by a T (thymidine) in the oncogene. This single base-pair replacement - a point mutation - appeared to be all that was required to convert the normal gene into a potent oncogene The H-ras gene This was the first time that a mutation was discovered in a gene that contributed to the growth of a human cancer. This genetic change arose as a somatic mutation. The importance of Ras proteins in tumors In the 1980s, it was demonstrated that close to 30% of all solid tumors in humans show a mutation in the Ras gene. Certain positions in the Ras protein are particularly sensitive to oncogenic mutations. Replacement of Gly12 in the Ras protein with any of the other natural amino acids (except Pro) leads to an increase in the tumor-transforming potential of Ras protein. RAS a switch protein Structure and Biochemical Properties of Ras Protein The Ras protein is a GTPase the GTP-bound form represents the active, switched-on state the GDP-bound form is the inactive, switched-off state The transition between the active and inactive forms occurs in a unidirectional cycle The Ras activation cycle Ras On… GEF Guanine Exchange Factors Sos protein Is a GEF that provokes nucleotide exchange by G proteins (guanine nucleotide-binding), such as Ras. Ras Off… GAP GTPase Activating Protein GTPase-activating proteins (GAP), increase the rate of GTP hydrolysis of the Ras protein up to 105-fold. reducing the lifetime of the active GTP state. Due to this property, they function as negative regulators of the Ras protein. Cancer Genetics in brief series… by Mark Temple
Views: 3888 Mark Temple
Medical vocabulary: What does ras Guanine Nucleotide Exchange Factors mean
 
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What does ras Guanine Nucleotide Exchange Factors mean in English?
Conformational Change from active (GTP bound) to inactive (GDP bound) state of H-Ras protein.
 
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Watch in 480p for best quality. Ras are a group of small GTPases which are activated by binding of GTP( Guanosine tri phosphate) a process which is facilated by GEF (Guanine nucleotide exchange factor) protein. The Ras which then activates its cellular target for conveying the signal downstream then hydrolyses the bound GTP ( process stimulated by another protein GAP (GTPase Activating Protein) to GDP which the dissociates and the protein returns to its inactive conformation.
Views: 5187 Perunamuusi
4.3 How is ras involved in signaling
 
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How is ras involved in the signaling Ras (oncogene) was known to be important in cancer Ras was known to be a molecular switch But was ras involved in the signaling from receptor to nucleus If so how? Ras as a molecular switch involves a conformational change Eye development in the fruit fly Drosophila melanogaster The gene sevenless - in its absence, the seventh cell in each ommatidium failed to form After cloning and sequencing the sevenless gene was found to encode a tyrosine kinase receptor (a bit like the EGF receptor) Eye development in the fruit fly other mutations mimicked sevenless Could this be a linear signal-transduction cascade e.g. son of sevenless (sos) Sos protein related to yeast proteins that provoking nucleotide exchange by G proteins (guanine nucleotide-binding), such as Ras. Other proteins make the pathway Shc (pronounced "shick”) Grb2 (pronounced "grab two”) We know have... GF-- TKR-- Grb2-- Sos-- Ras But... what is the role of Tyrosine Phosphorylation? Was the phosphorylation of these receptors on tyrosine residues critical to their ability to signal or was it a distraction? If this phosphorylation was important how could it activate the complex signaling circuitry downstream?
Views: 769 Mark Temple
Ras activator, Son of sevenless
 
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Ras is a proto-oncogene and is a member of small-molecular weight GTP binding protein family. This movie shows the mechanism of Ras activation by Sos (son of sevenless), a guanine-nucleotide exchange factor for Ras. The Cdc25-HD domain of Sos inserts into switch regions of Ras and excludes the binding of a guanine nucleotide and a magnesium ion, so that a GTP can be recruited subsequently. These structures also show a sophisticated mechanism for positive feedback regulation. A second molecule of Ras in its activated GTP-bound form interacts with the Cdc25-HD domain and its upstream REM domain to arrange the Sos domains for GTP exchange of the first Ras. In addition, the second Ras binding also inhibits the interaction with the auto-inhibitory DH-PH domains.
Views: 3520 StructureForBiology
Medical vocabulary: What does ral Guanine Nucleotide Exchange Factor mean
 
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What does ral Guanine Nucleotide Exchange Factor mean in English?
Views: 131 botcaster inc. bot
Figure 18.17 Determining the guanine nucleotide exchange properties of EF-Ts
 
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This video describes an experiment that shows that EF-Ts promotes the release of GDP from EF-Tu. This is figure 18.17 from Molecular Biology 5th edition by Robert Weaver. It was made for MCDB 427, a molecular biology course at the University of Michigan.
Views: 29 MCDB 427
Molecular Cloning of Rho Family Guanine Nucleotide Exchange Factors FGD1-5
 
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Student Achievement Day Presentation at Bemidji State University
Views: 122 bawani129
Medical vocabulary: What does rho Guanine Nucleotide Dissociation Inhibitor beta mean
 
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What does rho Guanine Nucleotide Dissociation Inhibitor beta mean in English?
[Wikipedia] RhoGEF domain
 
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RhoGEF domain is a structural domain of guanine nucleotide exchange factors for Rho/Rac/Cdc42-like GTPases. It is also called "Dbl-homologous" (DH) domain. https://en.wikipedia.org/wiki/RhoGEF_domain Please support this channel and help me upload more videos. Become one of my Patreons at https://www.patreon.com/user?u=3823907
Views: 11 WikiTubia
Medical vocabulary: What does Guanine Nucleotide Exchange Factors mean
 
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What does Guanine Nucleotide Exchange Factors mean in English?
Views: 108 botcaster inc. bot
Medical vocabulary: What does ras Guanine Nucleotide Exchange Factors mean
 
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What does ras Guanine Nucleotide Exchange Factors mean in English?
Views: 11 botcaster inc. bot
The Universe of GTP-binding proteins: un tema con variationi
 
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Air date: Wednesday, March 25, 2009, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local Category: Wednesday Afternoon Lectures Description: GTP binding (G) proteins of the Ras superfamily cycle between a GDP-bound inactive and a GTP-bound active state. The switch-ON reaction involves the exchange of tightly bound GDP against GTP, while the switch-OFF mechanism involves the enzymatic cleavage of GTP to GDP. The switch function is tightly regulated since those reactions are intrinsically very slow and are stimulated through factors acting in trans. The first reaction is catalysed by guanine nucleotide exchange factors, GEFs, while the second is activated by GTPase-activating proteins called GAPs. The inability of certain of these proteins to be down-regulated or their unregulated activation leads to various forms of diseases including cancer. A lot is known about the structural requirements for the switch function of Ras proteins, the GEF and the GAP reaction, their membrane recruitment and the interaction with effectors. The basic features and mechanistic principles using Ras and G proteins, the structural basis of the molecular switch, how it is activated and how it interacts with downstream effectors, will be presented. Particular attention will be given to the GTPase reaction and its importance for disease formation such as cancer, Retinitis pigmentosa or Parkinson. The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. Author: Alfred Wittenhofer Runtime: 00:58:32 Permanent link: http://videocast.nih.gov/launch.asp?14996
Views: 1205 nihvcast
Gene Music using Protein Sequence of ARHGEF7 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7"
 
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Gene Music using Protein Sequence of ARHGEF7 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music using Protein Sequence of ARHGEF6 "RAC/CDC42 GUANINE NUCLEOTIDE EXCHANGE FACTOR 6"
 
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Gene Music using Protein Sequence of ARHGEF6 "RAC/CDC42 GUANINE NUCLEOTIDE EXCHANGE FACTOR 6" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Medical vocabulary: What does rho Guanine Nucleotide Dissociation Inhibitor alpha mean
 
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What does rho Guanine Nucleotide Dissociation Inhibitor alpha mean in English?
Gene Music using Protein Sequence of RAPGEF6 "RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6"
 
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Gene Music using Protein Sequence of RAPGEF6 "RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1 Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences).
Views: 11 Gene Music Studio
Gene Music using Protein Sequence of RIC8A "RIC8 GUANINE NUCLEOTIDE EXCHANGE FACTOR A"
 
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Gene Music using Protein Sequence of RIC8A "RIC8 GUANINE NUCLEOTIDE EXCHANGE FACTOR A" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music using Protein Sequence of RAPGEFL1 "RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR LIKE 1"
 
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Gene Music using Protein Sequence of RAPGEFL1 "RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR LIKE 1"
Views: 22 Gene Music Studio
Gene Music using Protein Sequence of ARHGEF12 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF) 12"
 
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Gene Music using Protein Sequence of ARHGEF12 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF) 12" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1 Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences).
Views: 18 Gene Music Studio
Gene Music using Protein Sequence of RABGEF1 "RAB GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF) 1"
 
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Gene Music using Protein Sequence of RABGEF1 "RAB GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF) 1" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music using Protein Sequence of RAPGEF1 "RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"
 
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Gene Music using Protein Sequence of RAPGEF1 "RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1 Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences).
Gene Music Using Protein Sequence of ARHGEF38 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 38"
 
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Gene Music Using Protein Sequence of ARHGEF38 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 38"
Views: 18 Gene Music Studio
Medical vocabulary: What does Guanine Nucleotide-Releasing Factor 2 mean
 
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What does Guanine Nucleotide-Releasing Factor 2 mean in English?
Gene Music using Protein Sequence of ARHGEF37 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 37"
 
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Gene Music using Protein Sequence of ARHGEF37 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 37" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music using Protein Sequence of ARHGEF18 "RHO/RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR 18"
 
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Gene Music using Protein Sequence of ARHGEF18 "RHO/RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR 18" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1 Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences).
Gene Music using Protein Sequence of VAV3 "VAV 3 GUANINE NUCLEOTIDE EXCHANGE FACTOR"
 
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Gene Music using Protein Sequence of VAV3 "VAV 3 GUANINE NUCLEOTIDE EXCHANGE FACTOR" Welcome to Gene Music Studio. Hope you can have a taste (visually & musically) of gene information (particularly protein sequences) in this channel. Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music using Protein Sequence of SOS1 "SOS RAS/RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"
 
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Gene Music using Protein Sequence of SOS1 "SOS RAS/RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR 1" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1 Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences).
Gene Music using Protein Sequence of ARHGEF1 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"
 
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Gene Music using Protein Sequence of ARHGEF1 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music using Protein Sequence of ARHGEF39 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 39"
 
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Gene Music using Protein Sequence of ARHGEF39 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 39"
Medical vocabulary: What does rho-Specific Guanine Nucleotide Dissociation Inhibitors mean
 
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What does rho-Specific Guanine Nucleotide Dissociation Inhibitors mean in English?
Gene Music using Protein Sequence of ARHGEF35 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 35"
 
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Gene Music using Protein Sequence of ARHGEF35 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 35"
Medical vocabulary: What does Guanine Nucleotide Dissociation Inhibitors mean
 
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What does Guanine Nucleotide Dissociation Inhibitors mean in English?
Views: 20 botcaster inc. bot
Gene Music using Protein Sequence of TRIO "TRIO RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR"
 
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Gene Music using Protein Sequence of TRIO "TRIO RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1 Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences).
Views: 25 Gene Music Studio
Gene Music using Protein Sequence of ARHGEF2 "RHO/RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR 2"
 
02:02
Gene Music using Protein Sequence of ARHGEF2 "RHO/RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR 2" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1 Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences).
Gene Music using Protein Sequence of RIC8B "RIC8 GUANINE NUCLEOTIDE EXCHANGE FACTOR B"
 
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Gene Music using Protein Sequence of RIC8B "RIC8 GUANINE NUCLEOTIDE EXCHANGE FACTOR B" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music using Protein Sequence of RAPGEF5 "RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 5"
 
01:33
Gene Music using Protein Sequence of RAPGEF5 "RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 5" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel...
 
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A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis. Sabu Abraham et al (2015), Nature Communications http://dx.doi.org/10.1038/ncomms8286 During angiogenesis, Rho-GTPases influence endothelial cell migration and cell–cell adhesion; however it is not known whether they control formation of vessel lumens, which are essential for blood flow. Here, using an organotypic system that recapitulates distinct stages of VEGF-dependent angiogenesis, we show that lumen formation requires early cytoskeletal remodelling and lateral cell–cell contacts, mediated through the RAC1 guanine nucleotide exchange factor (GEF) DOCK4 (dedicator of cytokinesis 4). DOCK4 signalling is necessary for lateral filopodial protrusions and tubule remodelling prior to lumen formation, whereas proximal, tip filopodia persist in the absence of DOCK4. VEGF-dependent Rac activation via DOCK4 is necessary for CDC42 activation to signal filopodia formation and depends on the activation of RHOG through the RHOG GEF, SGEF. VEGF promotes interaction of DOCK4 with the CDC42 GEF DOCK9. These studies identify a novel Rho-family GTPase activation cascade for the formation of endothelial cell filopodial protrusions necessary for tubule remodelling, thereby influencing subsequent stages of lumen morphogenesis.
Views: 544 ScienceVio
Gene Music using Protein Sequence of ARHGEF15 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 15"
 
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Gene Music using Protein Sequence of ARHGEF15 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 15" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music using Protein Sequence of ARHGEF19 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 19"
 
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Gene Music using Protein Sequence of ARHGEF19 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 19" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1
Gene Music using Protein Sequence of ARHGEF10L "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10 LIKE"
 
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Gene Music using Protein Sequence of ARHGEF10L "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10 LIKE" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1 Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences).
Gene Music using Protein Sequence of ARHGEF17 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 17"
 
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Gene Music using Protein Sequence of ARHGEF17 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 17" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1 Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences).
Gene Music using Protein Sequence of ARHGEF11 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 11"
 
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Gene Music using Protein Sequence of ARHGEF11 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 11" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1 Gene Music Studio - A channel to taste (visually & musically) gene information (particularly protein sequences).
Gene Music using Protein Sequence of ARHGEF33 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 33"
 
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Gene Music using Protein Sequence of ARHGEF33 "RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 33" Subscribe ➜ https://www.youtube.com/c/GeneMusicStudio?sub_confirmation=1

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